Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters

Rodrigo Ruano, Marie Cécile Aubry, Bruno Barthe, Delphine Mitanchez, Yves Dumez, Alexandra Benachi

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design: In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results: The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls (P < .001) and in fetuses with CDH who died (P < .050). However, there was no significant association between PA diameters and PAH (P ≥ .050). Conclusions: The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalJournal of pediatric surgery
Issue number4
StatePublished - Apr 2008


  • Congenital diaphragmatic hernia
  • Fetal lung
  • Fetal malformation
  • Predictors of mortality
  • Pulmonary arteries
  • Pulmonary hypoplasia

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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