Abstract
Heart disease and diabetes are both highly prevalent in the population and contribute significantly to morbidity and mortality. Cardiometabolic derangements in diabetes, hyperglycemia, insulin resistance, and hyperinsulinemia result in microvascular and macrovascular damage, atherosclerosis and ischemic heart disease, platelet dysfunction and increased thrombosis, hypertension, myocyte hypertrophy, fibrosis, and heart failure. Diabetes is a risk factor for the development and progression of coronary heart disease and heart failure. Those with both cardiovascular risk and diabetes are at increased risk of myocardial infarctions, strokes, heart failure, and death compared to the general population. Management of diabetes and heart failure includes a combination of lifestyle modification as well as glycemic control. Newer pharmacologic agents such as SGLT2 inhibitors and GLP1 agonists may provide additional cardiovascular outcomes benefits.
| Original language | English (US) |
|---|---|
| Title of host publication | Precision Medicine in Diabetes |
| Subtitle of host publication | A Multidisciplinary approach to an Emerging Paradigm |
| Publisher | Springer International Publishing |
| Pages | 53-64 |
| Number of pages | 12 |
| ISBN (Electronic) | 9783030989279 |
| ISBN (Print) | 9783030989262 |
| DOIs | |
| State | Published - Jan 1 2022 |
Keywords
- Coronary artery disease
- Diabetes complications
- Diabetic cardiomyopathy
- Heart failure
- Heart failure treatment
- Heart failure with preserved ejection fraction
- Hyperlipidemia
- Hypertension
- Sodium glucose co-transporter 2 inhibitors
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- General Medicine