Precision Medicine Approaches to Cardiac Arrhythmias: JACC Focus Seminar 4/5

John R. Giudicessi, Michael J. Ackerman, Diane Fatkin, Jason C. Kovacic

Research output: Contribution to journalReview articlepeer-review


In the initial 3 papers in this Focus Seminar series, the fundamentals and key concepts of precision medicine were reviewed, followed by a focus on precision medicine in the context of vascular disease and cardiomyopathy. For the remaining 2 papers, we focus on precision medicine in the context of arrhythmias. Specifically, in this fourth paper we focus on long QT syndrome, Brugada syndrome, and atrial fibrillation. The final (fifth) paper will deal with catecholaminergic polymorphic ventricular tachycardia. These arrhythmias represent a spectrum of disease ranging from common to relatively rare, with very different genetic and environmental causative factors, and with differing clinical manifestations that range from almost no consequences to lethality in childhood or adolescence if untreated. Accordingly, the emerging precision medicine approaches to these arrhythmias vary significantly, but several common themes include increased use of genetic testing, avoidance of triggers, and personalized risk stratification to guide the use of arrhythmia-specific therapies.

Original languageEnglish (US)
Pages (from-to)2573-2591
Number of pages19
JournalJournal of the American College of Cardiology
Issue number20
StatePublished - May 25 2021


  • Brugada syndrome
  • atrial fibrillation
  • cardiac arrhythmia
  • genetic testing
  • genetics
  • long QT syndrome
  • precision medicine
  • sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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