Pre-mRNA splicing: a complex picture in higher definition

Matthew J. Schellenberg, Dustin B. Ritchie, Andrew M. MacMillan

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations


Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalTrends in biochemical sciences
Issue number6
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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