TY - JOUR
T1 - Pre-mRNA splicing
T2 - a complex picture in higher definition
AU - Schellenberg, Matthew J.
AU - Ritchie, Dustin B.
AU - MacMillan, Andrew M.
N1 - Funding Information:
We thank Edyta Sieminska for helpful comments on the manuscript. Work in the laboratory is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), and the Alberta Heritage Foundation for Medical Research (AHFMR).
PY - 2008/6
Y1 - 2008/6
N2 - Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery.
AB - Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery.
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U2 - 10.1016/j.tibs.2008.04.004
DO - 10.1016/j.tibs.2008.04.004
M3 - Short survey
C2 - 18472266
AN - SCOPUS:44749087058
SN - 0968-0004
VL - 33
SP - 243
EP - 246
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 6
ER -