Abstract
The effects of the lithium ion (Li+ ) on receptor-mediated synthesis of second messengers were determined, when cellular sodium channels were quiescent or excited, using the murine neuroblastoma clone (N1E-115). In this clone, lithium inhibited the receptor-mediated synthesis of cyclic AMP and cyclic GMP and it also increased the accumulation of inositol phosphates by a receptor-mediated process. When veratridine (20 μM) excited the sodium channel, the effects of lithium were potentiated. However, tetrodotoxin, a sodium channel blocker, completely prevented this potentiation. These results suggest that when neurons are depolarizing actively and intraneuronal levels of lithium increase by entry through the sodium channel, lithium has a more potent intracellular effect. As a result, lithium would have more potent and selective effects in those pathologically-active neurons underlying manic-depressive disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-500 |
| Number of pages | 4 |
| Journal | Neuropharmacology |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1991 |
Keywords
- cyclic AMP
- cyclic GMP
- inositol phosphates
- lithium ion
- sodium channel
- transmembrane control
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology