TY - JOUR
T1 - Potential reduction of post-acute sequelae of SARS-CoV-2 symptoms via vaccination
AU - Vanichkachorn, Greg
AU - Gilman, Elizabeth
AU - Ganesh, Ravindra
AU - Mueller, Michael
AU - Swift, Melanie
AU - Breeher, Laura
AU - Murad, M. Hassan
N1 - Publisher Copyright:
© 2023 American Federation for Medical Research.
PY - 2023/12
Y1 - 2023/12
N2 - The objective of this observational study is to determine whether vaccination for SARS-CoV-2 alters the clinical presentation of post-COVID conditions (PCC). Self-reported data provided by patients requesting care for PCC at the Mayo Clinic were analyzed to assess for a relationship between vaccination status prior to COVID infection and PCC symptoms. In all, 477 subjects were included in this study. In total, 245 (51.4%) were vaccinated. Vaccinated subjects with PCC reported less abdominal pain, anosmia, parosmia, chest pain/tightness, dizziness, numbness/tingling, dyspnea, spells/tremors, and weakness. For hospitalized patients who developed PCC, vaccinated patients reported less chest pain, cough, dizziness, and dyspnea. After applying Bonferroni correction for multiple comparisons, decreased abdominal pain remained significant. We conclude that vaccination against SARS-CoV-2 may reduce the symptoms of PCC, leading to improved morbidity and function. Further studies on the impact of vaccination on PCC and recovery are needed.
AB - The objective of this observational study is to determine whether vaccination for SARS-CoV-2 alters the clinical presentation of post-COVID conditions (PCC). Self-reported data provided by patients requesting care for PCC at the Mayo Clinic were analyzed to assess for a relationship between vaccination status prior to COVID infection and PCC symptoms. In all, 477 subjects were included in this study. In total, 245 (51.4%) were vaccinated. Vaccinated subjects with PCC reported less abdominal pain, anosmia, parosmia, chest pain/tightness, dizziness, numbness/tingling, dyspnea, spells/tremors, and weakness. For hospitalized patients who developed PCC, vaccinated patients reported less chest pain, cough, dizziness, and dyspnea. After applying Bonferroni correction for multiple comparisons, decreased abdominal pain remained significant. We conclude that vaccination against SARS-CoV-2 may reduce the symptoms of PCC, leading to improved morbidity and function. Further studies on the impact of vaccination on PCC and recovery are needed.
KW - COVID-19
KW - Post-acute sequelae of SARS-CoV-2
KW - long haul COVID
KW - pandemic
KW - vaccination
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U2 - 10.1177/10815589231191812
DO - 10.1177/10815589231191812
M3 - Article
C2 - 37497990
AN - SCOPUS:85174832245
SN - 1081-5589
VL - 71
SP - 889
EP - 895
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
IS - 8
ER -