TY - JOUR
T1 - Positron emission tomography for basal cell carcinoma of the head and neck
AU - Fosko, Scott W.
AU - Hu, Weimin
AU - Cook, Thomas F.
AU - Lowe, Val J.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Objective: To determine the ability of fluorodeoxyglucose F 18 positron emission tomography (FDG-PET) to image basal cell carcinoma (BCC). Design: Case series study. Setting: Mohs surgery practice in a tertiary university hospital. Patients: Six patients with BCC larger than 1.0 cm of the head and neck region were identified. Results: Patients were imaged using FDG-PET before surgery. In 3 patients, PET imaging correlated well with the size and extent of the soft tissue invasion. Histologically, all 3 tumors were of the nodular subtype. The remaining 3 patients failed to demonstrate identifiable tumor activity on PET. Two of these 3 tumors were of the infiltrative histologic subtype, and 1 was of the nodular subtype. Perineural spread was detected by tissue biopsy in 1 infiltrative tumor, but not by FDG-PET imaging. Conclusions: In our study, FDG-PET imaging was able to image and identify BCC in the head and neck region in 3 of 6 patients. In some cases, anatomic accuracy and the extent of soft tissue invasion were observed. The histologic subtype of the BCC appears to affect the ability of FDG-PET detection, with the nodular histologic subtype more likely to test positive on PET. This is a preliminary study, and future investigation is needed to evaluate the role of PET imaging in the management of patients with BCC.
AB - Objective: To determine the ability of fluorodeoxyglucose F 18 positron emission tomography (FDG-PET) to image basal cell carcinoma (BCC). Design: Case series study. Setting: Mohs surgery practice in a tertiary university hospital. Patients: Six patients with BCC larger than 1.0 cm of the head and neck region were identified. Results: Patients were imaged using FDG-PET before surgery. In 3 patients, PET imaging correlated well with the size and extent of the soft tissue invasion. Histologically, all 3 tumors were of the nodular subtype. The remaining 3 patients failed to demonstrate identifiable tumor activity on PET. Two of these 3 tumors were of the infiltrative histologic subtype, and 1 was of the nodular subtype. Perineural spread was detected by tissue biopsy in 1 infiltrative tumor, but not by FDG-PET imaging. Conclusions: In our study, FDG-PET imaging was able to image and identify BCC in the head and neck region in 3 of 6 patients. In some cases, anatomic accuracy and the extent of soft tissue invasion were observed. The histologic subtype of the BCC appears to affect the ability of FDG-PET detection, with the nodular histologic subtype more likely to test positive on PET. This is a preliminary study, and future investigation is needed to evaluate the role of PET imaging in the management of patients with BCC.
UR - http://www.scopus.com/inward/record.url?scp=0141819292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141819292&partnerID=8YFLogxK
U2 - 10.1001/archderm.139.9.1141
DO - 10.1001/archderm.139.9.1141
M3 - Article
C2 - 12975155
AN - SCOPUS:0141819292
SN - 0003-987X
VL - 139
SP - 1141
EP - 1146
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 9
ER -