Reinhard Hohlfeld, Andrew G. Engel, Marinos C. Dalakas

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: In his excellent review (Nov. 21 issue),1 Dr. Dalakas referred to a case of polymyositis that we described2 as one that was “mediated by T cells expressing the γ/δ receptor, which have cytotoxic activity restricted to the MHC-I [major-histocompatibility-complex class I] antigen.” We wish to emphasize that the mere colocalization of MHC-I antigen and γ/δ T cells does not necessarily imply that the antigen functions as the restrictive element of γ/δ T cells. Although the existence of γ/δ T cells recognizing MHC-I antigen has been formally demonstrated,3 the majority of such cells apparently recognize antigens either independently.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number19
StatePublished - May 7 1992

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Polymyositis'. Together they form a unique fingerprint.

Cite this