Polymeric delivery vehicles for bone growth factors

Lichun Lu, Susan J. Peter, Georgios N. Stamatas, Antonios G. Mikos

Research output: Contribution to journalConference articlepeer-review


The effects of polyethylene glycol (PEG) content and pH on in vitro transforming growth factor-β1 (TGF-β1) release kinetics and poly(DL-lactic-co-glycolic acid) (PLGA) degradation were studied, along with the effects of TGF-β1 released from the PLGA/PEG microparticles on the proliferation and differentiation of cultured primary rat marrow stromal cells. The release of TGF-β1 from the PLGA/PEG microparticles was increased by increasing the PEG content or buffer pH during the 28-day period. Increasing the PEG content also slightly increased PLGA degradation, while decreasing the pH significantly accelerated PLGA degradation. Significant increase in the alkaline phosphatase activity of cultured cell was observed at on optimal dosage of 1.0 ng/ml.

Original languageEnglish (US)
Pages (from-to)277-278
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Issue number1
StatePublished - Mar 1999
EventProceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA
Duration: Mar 21 1999Mar 25 1999

ASJC Scopus subject areas

  • Polymers and Plastics


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