Abstract
The fabrication of injectable self-cross-linkable hyperbranched poly(ϵ-caprolactone) (hyPCL) formulation using metal-free click chemistry was reported. The cross-linking between hyPCL32-(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethanol (hyPCL32-BCN) and hyPCL32-azide (hyPCL32-N3) components was proceeded via strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction. Cross-linking was tested to proceed effectively with the exclusion of any toxic cross-linking agents. Strong mechanical properties and excellent biocompatibility were demonstrated for the cross-linked substrates. These newly synthesized dendrimers may have broad applications in tissue engineering such as bone defect repair. In addition, the introduction of metal-free click chemistry to hydrophobic polymers provides an attractive new strategy for developing injectable stiff polymer formulations besides hydrogels for biomedical applications.
Original language | English (US) |
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Pages (from-to) | 1261-1265 |
Number of pages | 5 |
Journal | ACS Macro Letters |
Volume | 5 |
Issue number | 11 |
DOIs | |
State | Published - Nov 15 2016 |
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Materials Chemistry