POEMS syndrome and Castleman’s disease

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell disorder. The dominant feature is typically peripheral neuropathy, and the hematologic manifestations can be subtle leading to delayed diagnosis. Although the mechanism of disease is not well understood, the disease is very treatable, and survival is typically excellent. Castleman’s disease (CD) can occur with and without POEMS syndrome. Patients with unicentric CD have an excellent prognosis with local therapies; outcomes are less good, and therapies are less well established for the patients with multicentric CD with the exception of interleukin-6 and interleukin-6 receptor antibodies, which are useful in a subset of patients.

Original languageEnglish (US)
Title of host publicationBiology and Management of Unusual Plasma Cell Dyscrasias
PublisherSpringer New York
Number of pages29
ISBN (Electronic)9781441968487
ISBN (Print)9781441968470
StatePublished - Jan 1 2016


  • Castleman’s disease
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma
  • Osteosclerotic myeloma
  • POEMS syndrome
  • Paraneoplastic syndrome
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'POEMS syndrome and Castleman’s disease'. Together they form a unique fingerprint.

Cite this