POEMS Syndrome

Dimitrios C. Ziogas, Angela Dispenzieri, Evangelos Terpos

Research output: Chapter in Book/Report/Conference proceedingChapter


POEMS syndrome is a rare paraneoplastic condition due to an underlying plasma cell disorder that presents with a demyelinating peripheral neuropathy. The syndrome is most often associated with osteosclerotic bone lesions and high vascular endothelial growth factor. The other symptoms and signs would appear to be unrelated if one does not consider the diagnosis of this fascinating syndrome. Without adequate treatment, POEMS syndrome is progressive, disabling, and life-threatening. With treatment the prognosis is excellent when drugs from a myeloma armamentarium are employed.

Original languageEnglish (US)
Title of host publicationHematologic Malignancies
PublisherSpringer Verlag
Number of pages13
StatePublished - 2018

Publication series

NameHematologic Malignancies
ISSN (Print)2197-9766
ISSN (Electronic)2197-9774


  • Neuropathy
  • Osteosclerotic myeloma
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology


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