Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination

Moses Rodriguez, William E. Karnes, J. D. Bartleson, Alvaro A. Pineda

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.

Original languageEnglish (US)
Pages (from-to)1100-1104
Number of pages5
Issue number6
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination'. Together they form a unique fingerprint.

Cite this