Pituitary adenoma with tumoral granulomatous reaction

Bernd W. Scheithauer, Ana Isabel Silva, John L.D. Atkinson, Todd B. Nippoldt, Timothy J. Kaufmann, Kalman Kovacs, Eva Horvath, Ricardo Lloyd

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalEndocrine Pathology
Issue number2
StatePublished - Jun 2007


  • Granuloma
  • Inflammation
  • Pituitary
  • Silent corticotroph adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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