Pilot study of transesophageal endoscopic surgery: NOTES esophagomyotomy, vagotomy, lymphadenectomy

Timothy Woodward, David McCluskey, Michael B. Wallace, Massimo Raimondo, John Mannone, C. Daniel Smith

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objectives: The aim of this study was to evaluate the technical feasibility of endosonographically-assisted transesophageal access for vagotomy, esophagomyotomy, and lymphadenectomy in a nonsurvival study with six porcine models in an animal laboratory with general anesthesia. Mehods: Saline/hydroxypropylmethylcellulose (HPMC) was injected into the submucosa with a subsequent biliary balloon dissection, creating a substantial submucosal space for a cap-fitted endoscope. A distal esophageal myotomy was performed after access into the thoracic cavity. Over the course of 6 pigs, esophagomyotomy (simulating a Heller myotomy), vagotomy, and lymphadenectomy were performed. The esophageal insertion/access site was sealed by the flap of mucosa. Results: Using a midesophageal entrance point, successful thoracic access and therapeutic interventions involving the esophagus and periesophageal structures were performed in 6 pigs. Conclusions: The submucosal saline/HPMC tunneling technique allowed for successful access to the upper mediastinum through the esophagus with feasible therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)743-745
Number of pages3
JournalJournal of Laparoendoscopic and Advanced Surgical Techniques
Issue number5
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Surgery


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