Pilot evaluation of gabapentin for treating hot flashes

Charles L. Loprinzi, Debra L. Barton, Jeff A. Sloan, Katherine M. Zahasky, De Anne R. Smith, Sandhya Pruthi, Paul J. Novotny, Edith A. Perez, Bradley J. Christensen

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Objective: To obtain pilot prospective data regarding the efficacy and tolerability of gabapentin for alleviating hot flashes. Patients and Methods: This prospective single-arm clinical trial was conducted between July 26, 2001, and November 30, 2001. Patients underwent a baseline week and then 4 weeks of gabapentin treatment, with increasing doses during the first 3 weeks, from 300 to 600 to 900 mg/d. Data were obtained primarily from patient-completed questionnaires. Results: Data from 20 evaluable women (of 24 entered in the trial) were available. Four patients discontinued use of gabapentin for perceived drug-related untoward symptoms, primarily related to light-headedness and dizziness. The 16 patients who completed this clinical trial had a mean reduction in hot flash frequency, in the fourth treatment week compared to the baseline week, of 66%. Their corresponding hot flash score (frequency times average severity) reduction was 70%. Additionally, patients who completed the 4 treatment weeks had a strong tendency to report an improvement in several other symptoms. Conclusion: Although a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxicity of gabapentin in patients with hot flashes, the available data suggest that gabapentin is a reasonable treatment to consider in patients with hot flashes if they do not wish to use hormonal therapy.

Original languageEnglish (US)
Article number61804
Pages (from-to)1159-1163
Number of pages5
JournalMayo Clinic proceedings
Issue number11
StatePublished - Nov 2002

ASJC Scopus subject areas

  • Medicine(all)


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