TY - CHAP
T1 - Physical activity and trajectory of cognitive change in older persons
T2 - Mayo clinic study of aging
AU - Krell-Roesch, Janina
AU - Syrjanen, Jeremy A.
AU - Bezold, Jelena
AU - Trautwein, Sandra
AU - Barisch-Fritz, Bettina
AU - Boes, Klaus
AU - Woll, Alexander
AU - Forzani, Erica
AU - Kremers, Walter K.
AU - Machulda, Mary M.
AU - Mielke, Michelle M
AU - Knopman, David S
AU - Petersen, Ronald C.
AU - Vassilaki, Maria
AU - Geda, Yonas Endale
N1 - Publisher Copyright:
© 2024 IOS Press. All rights reserved.
PY - 2024/2/20
Y1 - 2024/2/20
N2 - Background: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults. Objective: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ε4 status. Methods: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid-or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores. Results: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ε4 carriership did not moderate the association between PA and cognition. Conclusion: Engaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.
AB - Background: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults. Objective: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ε4 status. Methods: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid-or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores. Results: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ε4 carriership did not moderate the association between PA and cognition. Conclusion: Engaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.
KW - Cognitive trajectories
KW - Community-dwelling persons
KW - Late-life
KW - Midlife
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=85189602999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85189602999&partnerID=8YFLogxK
U2 - 10.3233/AIAD230003
DO - 10.3233/AIAD230003
M3 - Chapter
AN - SCOPUS:85189602999
SN - 9781643684925
SP - 3
EP - 14
BT - Handbook of Prevention and Alzheimer's Disease
PB - IOS Press
ER -