Photoproteins as models of drug receptors

John R. Blinks; David G. Allen; Franklyn G. Prendergast; Gary C. Harrer

doi:10.1016/0024-3205(78)90092-9

Photoproteins as models of drug receptors

John R. Blinks, David G. Allen, Franklyn G. Prendergast, Gary C. Harrer

Pharmacology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.

Original language	English (US)
Pages (from-to)	1237-1244
Number of pages	8
Journal	Life Sciences
Volume	22
Issue number	13-15
DOIs	https://doi.org/10.1016/0024-3205(78)90092-9
State	Published - Apr 1978

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(78)90092-9

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@article{90745be5c9f6472ba658a3bdd6985dbb,

title = "Photoproteins as models of drug receptors",

abstract = "The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.",

author = "Blinks, {John R.} and Allen, {David G.} and Prendergast, {Franklyn G.} and Harrer, {Gary C.}",

note = "Funding Information: Acknowledgments . This work was supported by USPHS grant HL 12186 . Parts of it were done during the tenure of a British-American Research Fellowship of the American Heart Association and the British Heart Foundation (to D.G .A.) and a research fellowship from the Minnesota Heart Association (to F .G .P .) . The authors gratefully acknowledge use of the facilities of the Friday Harbor Laboratories, University of Washington, for the collection of sequorin .",

year = "1978",

month = apr,

doi = "10.1016/0024-3205(78)90092-9",

language = "English (US)",

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journal = "Life Sciences",

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AU - Blinks, John R.

AU - Allen, David G.

AU - Prendergast, Franklyn G.

AU - Harrer, Gary C.

N1 - Funding Information: Acknowledgments . This work was supported by USPHS grant HL 12186 . Parts of it were done during the tenure of a British-American Research Fellowship of the American Heart Association and the British Heart Foundation (to D.G .A.) and a research fellowship from the Minnesota Heart Association (to F .G .P .) . The authors gratefully acknowledge use of the facilities of the Friday Harbor Laboratories, University of Washington, for the collection of sequorin .

PY - 1978/4

Y1 - 1978/4

N2 - The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.

AB - The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.

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DO - 10.1016/0024-3205(78)90092-9

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VL - 22

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EP - 1244

JO - Life Sciences

JF - Life Sciences

IS - 13-15

ER -

Photoproteins as models of drug receptors

Abstract

ASJC Scopus subject areas

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