Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

Paolo Ortu, Glenn M. LaMuraglia, W. Gregory Roberts, Kevin T. Schomacker, Thomas F. Deutsch, Thomas J. Flotte, Tayyaba Hasan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

Original languageEnglish (US)
Title of host publicationLaser-Tissue Interaction III
EditorsSteven L. Jacques
Number of pages7
ISBN (Electronic)9780819407924
StatePublished - Aug 7 1992
EventLaser-Tissue Interaction III 1992 - Los Angeles, United States
Duration: Jan 19 1992Jan 24 1992

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


OtherLaser-Tissue Interaction III 1992
Country/TerritoryUnited States
CityLos Angeles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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