Phosphorus disorders: Hypophosphatemic rickets

Research output: Chapter in Book/Report/Conference proceedingChapter


Phosphorus is a critical element for skeletal development and maturation, as well as bone mineralization, cell membrane structure, nucleotide formation, and intracellular signaling. Phosphorus forms complexes with oxygen in living tissues to form anionic phosphate. Phosphate homeostasis in humans is largely maintained by the balance between parathyroid hormone (PTH), 1,25-dihydroxyvitamin D, and fibroblast growth factor-23 (FGF-23). Serum phosphorus is influenced by these hormones, as well as by dietary intake, acid-based changes in the blood, renal function, skeletal metabolism, and intestinal absorption.

Original languageEnglish (US)
Title of host publicationMetabolic Bone Diseases
Subtitle of host publicationA Case-Based Approach
PublisherSpringer International Publishing
Number of pages16
ISBN (Electronic)9783030036942
ISBN (Print)9783030036935
StatePublished - Jan 1 2019


  • 25-Dihydroxyvitamin D
  • Autosomal-dominant hypophosphatemic rickets
  • FGF-23 1
  • Hypophosphatemia
  • Osteomalacia
  • Rickets
  • Tumor-induced osteomalacia
  • X-linked hypophosphatemic rickets

ASJC Scopus subject areas

  • General Medicine


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