Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke

James F. Meschia, Thomas G. Brott, Robert D. Brown, Richard Crook, Bradford B. Worrall, Brett Kissela, W. Mark Brown, Stephen S. Rich, L. Douglas Case, E. Whitney Evans, Stephen Hague, Andrew Singleton, John Hardy

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP. Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single-nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations.

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalAnnals of neurology
Issue number3
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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