Pheochromocytoma and Paraganglioma in Pregnancy: a New Era

Lucinda M. Gruber, William F. Young, Irina Bancos

Research output: Contribution to journalReview articlepeer-review


Purpose of review: Pheochromocytoma and paraganglioma (PPGL) in pregnancy is a rare entity and management of these patients is fraught with uncertainty. Our objective is to review current literature and discuss diagnosis and management of these patients. Recent findings: Outcomes of PPGL in pregnancy have improved in recent years. The greatest risk for adverse maternal and fetal outcomes is the diagnosis of PPGL after delivery. Alpha- and beta-adrenergic blockade is well tolerated and is associated with less adverse outcomes. Antepartum surgery is not associated with improved maternal or fetal outcomes. Biochemical testing and cross-sectional imaging should be performed prior to conception for patients with a known germline variant associated with PPGL. Conclusions: Medical therapy should be initiated when PPGL is diagnosed in pregnancy. Antepartum surgery should be reserved for special circumstances. Case detection testing in high-risk patients can identify PPGL before pregnancy.

Original languageEnglish (US)
Article number60
JournalCurrent cardiology reports
Issue number6
StatePublished - Jun 2021


  • Alpha-adrenergic blockade
  • Beta-adrenergic blockade
  • Paraganglioma
  • Pheochromocytoma
  • Pregnancy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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