Abstract
Background: The primary objective of this study was to compare the overall survival (OS) of patients with anaplastic astrocytoma (AA) treated with radiotherapy (RT) and either temozolomide (TMZ) or a nitrosourea (NU). Secondary endpoints were time to tumor progression (TTP), toxicity, and the effect of IDH1 mutation status on clinical outcome. Methods: Eligible patients with centrally reviewed, histologically confirmed, newly diagnosed AA were randomized to receive either RT+TMZ (n = 97) or RT+NU (n = 99). The study closed early because the target accrual rate was not met. Results: Median follow-up time for patients still alive was 10.1 years (1.9.12.6 y); 66% of the patients died. Median survival time was 3.9 years in the RT/TMZ arm (95% CI, 3.0.7.0) and 3.8 years in the RT/NU arm (95% CI, 2.2.7.0), corresponding to a hazard ratio (HR) of 0.94 (P =.36; 95% CI, 0.67.1.32). The differences in progression-free survival (PFS) and TTP between the 2 arms were not statistically significant. Patients in the RT+NU arm experienced more grade.3 toxicity (75.8% vs 47.9%, P <.001), mainly related to myelosuppression. Of the 196 patients, 111 were tested for IDH1-R132H status (60 RT+TMZ and 51 RT+NU). Fifty-four patients were IDH negative and 49 were IDH positive with a better OS in IDH-positive patients (median survival time 7.9 vs 2.8 y; P =.004, HR = 0.50; 95% CI, 0.31.0.81). Conclusions: RT+TMZ did not appear to significantly improve OS or TTP for AA compared with RT+ NU. RT+TMZ was better tolerated. IDH1-R132H mutation was associated with longer survival.
Original language | English (US) |
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Pages (from-to) | 252-258 |
Number of pages | 7 |
Journal | Neuro-oncology |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - 2017 |
Keywords
- Anaplastic astrocytoma
- Nitrosourea
- Radiotherapy
- Temozolomide
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
- Cancer Research