Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women

M. E. Meekins, S. S. Oberhelman, B. R. Lee, B. M. Gardner, S. S. Cha, R. J. Singh, J. M. Pettifor, P. R. Fischer, T. D. Thacher

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC 28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC 28 compared with the daily group (P<0.001).

Original languageEnglish (US)
Pages (from-to)632-634
Number of pages3
JournalEuropean journal of clinical nutrition
Issue number5
StatePublished - May 2014


  • metabolism
  • pharmacokinetics
  • vitamin D
  • women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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