Phalloidin suppresses the force in nebulin-rich lamprey cardiac muscle

A. E. Bukatina, J. Korinek, G. C. Sieck, M. Belohlavek

Research output: Contribution to journalArticlepeer-review


The effect of phalloidin, an agent detaching nebulin from actin in skeletal muscle, on the isometric force in lamprey skinned cardiac muscle, which has nebulin in amounts comparable to that in skeletal muscle, has been studied. We found that, unlike mammalian cardiac muscle expressing nebulin less abundantly and responding to phalloidin by a force increase, lamprey cardiac muscle responds to phalloidin by a force decrease (approximately 50% decrease), thereby resembling the response of skeletal muscle. These results support our hypothesis that nebulin detachment from actin underlies phalloidin-induced force loss and suggest a role of actin-nebulin interaction in contractile function.

Original languageEnglish (US)
Pages (from-to)894-897
Number of pages4
Issue number5
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Medicine(all)


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