Peripheral T-cell lymphoma not otherwise specified

Research output: Chapter in Book/Report/Conference proceedingChapter


Peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS) is a heterogeneous group of diseases, where all the not otherwise classifiable mature T-cell lymphomas are grouped. In this chapter, the authors review the clinical characteristics and underlying biology of PTCL-NOS with a focus on their potential clinical implications. They also briefly discuss advances in management both in the frontline and relapsed setting. The Prognostic Index, a prognostic tool specifically designed for PTCL-NOS, was able to discriminate between four risk groups: no adverse prognostic factors (group 1), one (group 2), two (group 3) or three to four (group 4) adverse prognostic factors. The limitations of effective therapies, both at the frontline and the relapsed setting in PTCL, highlight the need for more mechanistic therapeutic approaches. The future is clearly in developing combination therapies that are rationally chosen based on disease biology.

Original languageEnglish (US)
Title of host publicationThe Peripheral T-Cell Lymphomas
Number of pages8
ISBN (Electronic)9781119671336
ISBN (Print)9781119671312
StatePublished - Feb 19 2021


  • Clinical characteristics
  • Disease biology
  • Frontline therapy
  • Peripheral T-cell lymphoma not otherwise specified
  • Prognostic factors
  • Relapsed setting
  • Therapeutic approaches

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Peripheral T-cell lymphoma not otherwise specified'. Together they form a unique fingerprint.

Cite this