Peripheral nerve microenvironment: Collection of endoneurially enriched fluid

Phillip A. Low, Jeffrey K. Yao, Joseph F. Poduslo, David E. Donald, Peter J. Dyck

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We report the first successful collection and biochemical analysis of endoneurially enriched fluid (EEF) from sciatic nerve of control and lead-intoxicated rats using an implanted polyethylene matrix capsule and collector. The EEF protein concentration was approximately one-half that of rat serum. Protein fractionation by sodium dodecyl sulfate-pore gradient electrophoresis revealed a different protein composition for the endoneurium, EEF, and serum from the same animal. In EEF there is a complex array of protein bands with a molecular weight range of 104 to 2 × 105 of which albumin was a major constituent. Preliminary results on lead-intoxicated rats suggest that total endoneurial fluid protein may be increased during lead intoxication.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalExperimental Neurology
Issue number1
StatePublished - Jul 1982

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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