Periosteum responds to dynamic fluid pressure by proliferating In vitro

D. B.F. Saris, A. Sanyal, K. N. An, J. S. Fitzsimmons, S. W. O'Driscoll

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The effect of dynamic fluid pressure on cell proliferation in periosteal tissue cultures was determined in explants from 60 immature New Zealand White rabbits. Dynamic fluid pressure increased proliferation of periosteal cells significantly, as indicated by a significant increase in [3H]thymidine uptake at all time points and a higher amount of DNA compared with control values. Cell proliferation in the early stages of chondrogenesis was stimulated by mechanical factors.

Original languageEnglish (US)
Pages (from-to)668-677
Number of pages10
JournalJournal of Orthopaedic Research
Issue number5
StatePublished - 1999

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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