Perinatal outcomes of fetal intra-abdominal umbilical vein varix: a multicenter cohort study

Victoria Novoa, Sherif Shazly, Eniola R. Ibirogba, Laura Sutton, Gabriele Tonni, Federico Prefumo, Waldo Sepulveda, Edward Araujo Júnior, Heron Werner, Mari Charisse Trinidad, Rodrigo Ruano

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: To investigate the perinatal outcomes of fetuses with antenatal diagnoses of intra-abdominal umbilical vein varix (UVV). Methods: A multicenter retrospective study was conducted in four countries on fetuses diagnosed with intra-abdominal UVV between 2012 and 2019. Collected data included gestational age (GA), UVV maximum diameter at diagnosis and delivery, associated anatomical and chromosomal anomalies, birth weight, and neonatal outcomes. Results: Twenty fetuses were identified, of which 20% had associated chromosomal and/or anatomical abnormalities, most resulting in poor outcomes (either intrauterine fetal death or pregnancy termination). Mean maternal age was 34.1 ± 7.0 years, UVV was diagnosed at 26.5 ± 4.5 weeks of GA on average with a maximum diameter of 12.0 ± 4.0 mm. Mean GA at delivery was 35.4 ± 5.6 weeks. Survival rate was 85%. Conclusion: Our study shows a satisfactory outcome when intra-abdominal UVV is an isolated finding, with minimal obstetrical and perinatal consequences. The prognosis is worse when UVV is associated with other anomalies.

Original languageEnglish (US)
Pages (from-to)3393-3396
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number20
StatePublished - 2021


  • Fetal ultrasound
  • prenatal diagnosis
  • thrombosis
  • umbilical vein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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