Perfluoroctylbromide as a gastrointestinal contrast agent for MR imaging: Use with and without glucagon

Jeffrey J. Brown, James R. Duncan, Jay P. Heiken, Dennis M. Balfe, Andrew P. Corr, Scott A. Mirowitz, Steven S. Eilenberg, Joseph K.T. Lee

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The utility of perfluoroctylbromide (PFOB) as a gastrointestinal contrast agent for magnetic resonance (MR) imaging was evaluated with MR examinations performed in 30 subjects (16 healthy volunteers and 14 patients). Transaxial T1-, proton density-, and T2-weighted MR images were acquired in each subject before and after the administration of PFOB. The healthy volunteers each underwent two sets of post-PFOB MR examinations, one before and one after glucagon administration. The degree of bowel marking, clarity of bowel-wall visualization, ability to distinguish bowel from adjacent parenchymal organs, and severity of phase-encoding artifacts were independently analyzed by two reviewers. Oral administration of PFOB significantly (P < .001) increased the percentage of bowel loops with low signal intensity. Subcutaneous administration of glucagon significantly (P < .001) increased the clarity of bowel-wall visualization on post-PFOB MR studies. The severity of phase-encoding artifacts did not change substantially after administration of PFOB or glucagon.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
Issue number2
StatePublished - Nov 1991


  • Contrast media, experimental studies
  • Gastrointestinal tract, MR studies, 70.1214, 70.1283
  • Glucagon
  • Magnetic resonance (MR), contrast enhancement
  • Perfluoroctylbromide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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