Percutaneous treatment of aortic and mitral valve paravalvular regurgitation

Mario Gössl, Charanjit S. Rihal

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Percutaneous paravalvular leak closure represents a small but important niche in structural interventions in the current era of interventional cardiology. It is estimated that paravalvular regurgitation affects 5-17 % of all surgically implanted prosthetic heart valves (which equates to 500 to 10,200 cases annually). Patients may present with clinical signs and evidence of heart failure, hemolysis or both. Due to the increased morbidity and mortality, reoperation is often best avoided, especially if the underlying perivalvular tissue is friable or heavily calcified. Perimitral defects are usually approached in an antegrade approach via a transeptal puncture; periaortic defects usually in a retrograde approach. Depending on the number, size and shape of the defect(s) - as determined by 2D and 3D echocardiography - one or multiple closure devices are deployed using various wiring and anchor techniques. This brief review provides a summary of the currently applied paravalvular leak closure techniques.

Original languageEnglish (US)
Article number388
JournalCurrent cardiology reports
Issue number8
StatePublished - Aug 2013


  • Amplatzer vascular plug
  • Antegrade
  • Aortic valve prosthesis
  • Heart failure
  • Hemolysis
  • Mitral valve prosthesis
  • Paravalvular leak
  • Paravalvular regurgitation
  • Percutaneous treatment
  • Retrograde
  • Transapical
  • Transseptal

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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