TY - JOUR
T1 - Percutaneous Fluoroscopic-Guided Endomyocardial Delivery in an Experimental Model of Left Ventricular Assist Device Support
AU - Dalén, Magnus
AU - Behfar, Atta
AU - Terzic, Andre
AU - Schiller, Petter
AU - Seron, Aymeric
AU - Sherman, Warren
AU - Månsson-Broberg, Agneta
AU - Grinnemo, Karl Henrik
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/8/7
Y1 - 2015/8/7
N2 - Endomyocardial delivery in the setting of active left ventricular assist device (LVAD) support has rarely been studied. The objective was to establish a protocol for endomyocardial injections during LVAD support without compromising mechanical circulation. LVAD implantation was performed in four pigs. A curved needle catheter was percutaneously inserted into the right carotid artery and positioned into the left ventricle under fluoroscopic guidance. In the setting of increasing LVAD flows (2.3–3.1 l/min), percutaneous methylene blue dye administration into the myocardium proceeded without complications in all pigs. Transection of excised hearts revealed an anterior, lateral, inferior, and septal wall distribution of methylene blue documenting injections in all four regions of the left ventricle. Ex vivo, the catheter could be maneuvered close to the LVAD inflow cannula despite augmentation of LVAD flow up to 5 l/min. Endomyocardial injections during LVAD support was found to be feasible and safe with the curved needle catheter.
AB - Endomyocardial delivery in the setting of active left ventricular assist device (LVAD) support has rarely been studied. The objective was to establish a protocol for endomyocardial injections during LVAD support without compromising mechanical circulation. LVAD implantation was performed in four pigs. A curved needle catheter was percutaneously inserted into the right carotid artery and positioned into the left ventricle under fluoroscopic guidance. In the setting of increasing LVAD flows (2.3–3.1 l/min), percutaneous methylene blue dye administration into the myocardium proceeded without complications in all pigs. Transection of excised hearts revealed an anterior, lateral, inferior, and septal wall distribution of methylene blue documenting injections in all four regions of the left ventricle. Ex vivo, the catheter could be maneuvered close to the LVAD inflow cannula despite augmentation of LVAD flow up to 5 l/min. Endomyocardial injections during LVAD support was found to be feasible and safe with the curved needle catheter.
KW - Catheters
KW - Delivery
KW - Endomyocardial
KW - Heart failure
KW - Left ventricular assist device
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U2 - 10.1007/s12265-015-9642-4
DO - 10.1007/s12265-015-9642-4
M3 - Article
C2 - 26149227
AN - SCOPUS:84938739083
SN - 1937-5387
VL - 8
SP - 381
EP - 384
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 6
ER -