Percutaneous Coronary Revascularization: JACC Historical Breakthroughs in Perspective

Patrick W. Serruys, Masafumi Ono, Scot Garg, Hironori Hara, Hideyuki Kawashima, Giulio Pompilio, Daniele Andreini, David R. Holmes, Yoshinobu Onuma, Spencer B. King

Research output: Contribution to journalReview articlepeer-review


Over the last 4 decades, percutaneous coronary intervention has evolved dramatically and is now an acceptable treatment option for patients with advanced coronary artery disease. However, trialists have struggled to establish the respective roles for percutaneous coronary intervention and coronary artery bypass graft surgery, especially in patients with multivessel disease and unprotected left-main stem coronary artery disease. Several pivotal trials and meta-analyses comparing these 2 revascularization strategies have enabled the relative merits of each technique to be established with regard to the type of ischemic syndrome, the coronary anatomy, and the patient's overall comorbidity. Precision medicine with individualized prognosis is emerging as an important method of selecting treatment.

Original languageEnglish (US)
Pages (from-to)384-407
Number of pages24
JournalJournal of the American College of Cardiology
Issue number4
StatePublished - Jul 27 2021


  • coronary artery bypass graft
  • coronary artery disease
  • drug-eluting stent
  • percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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