Peptide-based formula: Clinical applications and benefits

Osman Mohamed Elfadil, Raj N. Shah, Ryan T. Hurt, Manpreet S. Mundi

Research output: Contribution to journalReview articlepeer-review


The use of enteral nutrition (EN) continues to increase given benefits. However, with this increase in use, it is also becoming evident that enteral feeding intolerance (EFI) is also quite prevalent, leading to the inability to meet nutrition needs in many patients. Given the wide variability in the EN population as well as the number of formulas available, there is not a clear consensus regarding the best approach to EFI management. One approach that is emerging to improve EN tolerance is the use of peptide-based formulas (PBFs). PBFs refer to enteral formulas containing proteins that have been enzymatically hydrolyzed to dipeptides and tripeptides. These hydrolyzed proteins are often combined with higher medium-chain triglyceride content to generate an enteral formula that is essentially easier to absorb and utilize. Emerging data demonstrate that the use of PBF in patients with EFI may improve clinical outcomes along with a corresponding reduction in healthcare utilization and potentially the cost of care. This review aims to navigate through key clinical applications and benefits of PBF and to discuss relevant data shared in the literature.

Original languageEnglish (US)
Pages (from-to)318-328
Number of pages11
JournalNutrition in Clinical Practice
Issue number2
StatePublished - Apr 2023


  • enteral nutrition
  • formulas
  • nutrition support
  • peptides
  • tube feeding

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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