TY - JOUR
T1 - Pediatric NMOSD
T2 - A Review and Position Statement on Approach to Work-Up and Diagnosis
AU - The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC)
AU - Tenembaum, Silvia
AU - Yeh, E. Ann
AU - Abboud, Hesham
AU - Aktas, Orhan
AU - Alroughani, Raed
AU - Altintas, Ayse
AU - Amezcua, Lilyana
AU - Apiwattanakul, Metha
AU - Asgari, Nasrin
AU - Banwell, Brenda
AU - Bennett, Jeffrey
AU - Bichuetti, Denis
AU - Blaschke, Terrence F.
AU - Bowen, James
AU - Boyko, Alexey
AU - Brandt, Alexander
AU - Broadley, Simon
AU - Brück, Wolfgang
AU - Contentti, Edgar Carnero
AU - Carruthers, Robert
AU - Chitnis, Tanuja
AU - Cohen, Jeffrey
AU - Delgado-García, Guillermo
AU - Basuroski, Irena Dujmovic
AU - Evangelou, Nikos
AU - Fujihara, Kazuo
AU - Goodman, Andrew
AU - Greenberg, Benjamin
AU - Hacohen, Yael
AU - Han, May
AU - Havla, Joachim
AU - Hellwig, Kerstin
AU - Hor, Jyh Yung
AU - Iorio, Raffaele
AU - Jacob, Anu
AU - Jarius, Sven
AU - Arango, Jorge Andres Jimenez
AU - Sand, Ilana Katz
AU - Kim, Ho Jin
AU - Kim, Sung Min
AU - Kimbrough, Dorlan
AU - Kissani, Najib
AU - Klawiter, Eric
AU - Kleiter, Ingo
AU - Lana-Peixoto, Marco
AU - Leite, Maria Isabel
AU - Levy, Michael
AU - Liu, Yaou
AU - Lublin, Fred
AU - Wingerchuk, Dean
N1 - Publisher Copyright:
© Copyright © 2020 Tenembaum, Yeh and The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC).
PY - 2020/6/25
Y1 - 2020/6/25
N2 - Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown in recent years, particularly in light of newer information regarding the importance of not only antibodies to aquaporin 4 (AQP4-IgG) but also myelin oligodendrocyte glycoprotein (MOG-IgG) in children manifesting clinically with this syndrome. In this review, we describe the current state of the knowledge related to clinical manifestations, diagnosis, and chronic therapies for children with NMOSD, with emphasis on literature that has been published in the last 5 years. Following the review, we propose recommendations for the assessment/follow up clinical care, and treatment of this population.
AB - Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown in recent years, particularly in light of newer information regarding the importance of not only antibodies to aquaporin 4 (AQP4-IgG) but also myelin oligodendrocyte glycoprotein (MOG-IgG) in children manifesting clinically with this syndrome. In this review, we describe the current state of the knowledge related to clinical manifestations, diagnosis, and chronic therapies for children with NMOSD, with emphasis on literature that has been published in the last 5 years. Following the review, we propose recommendations for the assessment/follow up clinical care, and treatment of this population.
KW - MOG
KW - NMOSD
KW - diagnosis
KW - neuroinflammation
KW - pediatric
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85087739797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087739797&partnerID=8YFLogxK
U2 - 10.3389/fped.2020.00339
DO - 10.3389/fped.2020.00339
M3 - Review article
AN - SCOPUS:85087739797
SN - 2296-2360
VL - 8
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 339
ER -