Pathophysiology of Sports-Related Concussion

Kristen Steenerson, Amaal Starling

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Concussion pathophysiology is complicated and involves numerous mechanisms, including excessive neurotransmitter release, metabolic derangements, neuroinflammation, cerebral blood flow changes, and axonal disruption. The initial biomechanical impact in a concussion results in abnormal function at the cellular level, which initiates a cascade of events that leads to microstructural changes and, in the minority of cases, more persistent, permanent damage.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalNeurologic Clinics
Issue number3
StatePublished - Aug 1 2017


  • Concussion
  • TBI
  • Trauma
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology


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