Pathophysiology of GERD: Lower Esophageal Sphincter defects

Marcia C. Mitre, David A. Katzka

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The main function of the Lower Esophageal Sphincter (LES) is to serve as a barrier to protect the esophageal mucosa and more proximal structures from potentially damaging substances. Incompetence in some form of the LES is the predominant determinant of GERD. This article reviews the three main LES defects that lead to GERD.

Original languageEnglish (US)
Pages (from-to)44-58
Number of pages15
JournalPractical Gastroenterology
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Pathophysiology of GERD: Lower Esophageal Sphincter defects'. Together they form a unique fingerprint.

Cite this