Pathophysiological roles of PPARγ in gastrointestinal epithelial cells

Brian M. Necela, E. Aubrey Thompson

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Although the highest levels of PPARγ expression in the body have been reported in the gastrointestinal epithelium, little is known about the physiological functions of that receptor in the gut. Moreover, there is considerable controversy concerning the effects of thiazolidinedione PPARγ agonists on the two major diseases of the gastrointestinal track: colorectal cancer and inflammatory bowel disease. We will undertake to review both historical and recently published data with a view toward summarizing what is presently known about the roles of PPARγ in both physiological and pathological processes in the gastrointestinal epithelium.

Original languageEnglish (US)
Article number148687
JournalPPAR Research
StatePublished - 2008

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology (medical)


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