Pathology: What may it tell us?

Claudia F. Lucchinetti, Joseph E. Parisi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that affects approximately one million people worldwide and is the most common cause of nontraumatic disability in young adults (1). The cardinal features of the MS lesion, namely focal demyelination with relative axonal sparing, inflammation, and gliosis, were described and illustrated over 160 years ago by Carswell (1838), Cruveilher (1841), and Charcot (1868, 1880).

Original languageEnglish (US)
Title of host publicationHandbook of Multiple Sclerosis, Fourth Edition
PublisherCRC Press
Number of pages40
ISBN (Electronic)9781420018714
ISBN (Print)9781574448276
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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