Pathogenesis of ANCA-associated vasculitis

Rodrigo Cartin-Ceba, Tobias Peikert, Ulrich Specks

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Antineutrophil cytoplasmic autoantibodies (ANCA)- associated vasculitides (AAV) are a group of systemic vasculitis syndromes characterized by inflammation and necrosis of blood vessel walls. Genetic, epigenetic, and environmental factors contribute to the etiology and pathogenesis of AAV. On the basis of currently available clinical and experimental evidence, it is reasonable to believe that, in predisposed patients, different triggers can lead to the production of autoantibodies (ANCA) that, in the context of an inflammatory environment, can cause tissue inflammation and vascular injury. Several different pathways and mechanisms in the pathogenesis of AAV are described in this contemporary review.

Original languageEnglish (US)
Pages (from-to)481-493
Number of pages13
JournalCurrent rheumatology reports
Issue number6
StatePublished - Dec 2012


  • ANCA
  • ANCA-associated vasculitis
  • Eosinophilic granulomatosis with polyangiitis
  • Etiology
  • Granulomatosis with polyangiitis
  • Microscopic polyangiitis
  • Pathogenesis

ASJC Scopus subject areas

  • Rheumatology


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