Patent foramen ovale transcatheter closure device thrombosis

Vuyisile T. Nkomo, Pierre Theuma, Calin V. Maniu, Krishnaswamy Chandrasekaran, Fletcher A. Miller, Hartzell V. Schaff, George W. Petty, Todd D. Miller

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The role of patent ovale (PFO) in patients with cryptogenic stroke (stroke of unknown cause) remains controversial, although an association seems likely in younger patients with septal anuerysms and PFO. The mechanism of cryptogenic embolism via right-to-left shunt across the PFO. The available options for treatment include medical therapy with antiplatelet or anticoagulant therapy or closure of the PFOP closure devices. We describe 2 cases of bilateral device thrombosis associated with the use of a transcatheter PFO closure device (CardioSEAL). To our knowledge, only 1 other case thrombvosis associated with use of this device has been reported.

Original languageEnglish (US)
Article number62491
Pages (from-to)1057-1061
Number of pages5
JournalMayo Clinic proceedings
Issue number10
StatePublished - Oct 2001


  • APC-R = activated protein C resistance
  • ASD = atrial septal defect
  • DVT = deep venous thrombosis
  • INR = international normalized ratio
  • PFO = patent foramen ovale
  • TEE = transesophageal echocardiography
  • TIA = transient ischemic attack
  • TTE = transthoracic echocardiography

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Patent foramen ovale transcatheter closure device thrombosis'. Together they form a unique fingerprint.

Cite this