Parkinsonism, Lrrk2 G2019S, and tau neuropathology

A. Rajput, D. W. Dickson, C. A. Robinson, O. A. Ross, J. C. Dächsel, S. J. Lincoln, S. A. Cobb, M. L. Rajput, M. J. Farrer

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.

Original languageEnglish (US)
Pages (from-to)1506-1508
Number of pages3
Issue number8
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Clinical Neurology


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