Parathyroid hormone–related protein and hypercalcemia secondary to massive mammary hyperplasia

Sundeep Khosla, Jon A. Van Heerden, Hossein Gharib, Ian T. Jackson, Janine Danks, John A. Hayman, T. J. Martin

Research output: Contribution to journalLetterpeer-review

97 Scopus citations


To the Editor: Parathyroid hormone-related protein (PTHRP) is a recently characterized 141-amino acid peptide that is responsible for the humoral hypercalcemia of cancer.1 We previously reported on a patient with massive mammary hyperplasia occurring during pregnancy who had hypercalcemia that resolved after bilateral mastectomy.2 Recent studies done on tissue from this patient implicate PTHRP as the likely etiologic factor in her hypercalcemia. The patient was a 25-year-old woman who presented with bilateral breast enlargement of two months' duration. She was 24 weeks pregnant at that time. She had had two uneventful earlier pregnancies and had never had nonpuerperal galactorrhea. She.

Original languageEnglish (US)
Pages (from-to)1157
Number of pages1
JournalNew England Journal of Medicine
Issue number16
StatePublished - Apr 19 1990

ASJC Scopus subject areas

  • General Medicine


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