Paraneoplastic lower motor neuronopathy associated with Hodgkin lymphoma

Eoin P. Flanagan, Paola Sandroni, Sean J. Pittock, David J. Inwards, Lyell K. Jones

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Introduction: Paraneoplastic lower motor neuronopathies have been reported rarely with Hodgkin lymphoma. Methods: We report a case of rapidly progressive motor neuronopathy preceding the diagnosis of Hodgkin lymphoma. Results: A 31-year-old woman developed subacute rapidly progressive quadriparesis. Electrodiagnostic studies revealed a severe diffuse disorder of motor neurons and their axons. Symmetric enhancement of the cauda equina motor nerve roots was notable on magnetic resonance imaging scan. Further imaging demonstrated an enlarged supraclavicular lymph node, and biopsy revealed Hodgkin lymphoma. A final diagnosis of paraneoplastic motor neuronopathy was made after investigations for alternative causes of motor neuronopathy were unrevealing. Neurological improvement was seen with combined treatment of the underlying malignancy and intravenous immunoglobulin. Conclusions: Paraneoplastic causes should be considered in the differential diagnosis of subacute motor neuronopathy, as the neurological presentation may precede cancer detection. Combinations of lymphoma treatment and immunotherapy may result in a favorable outcome.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalMuscle and Nerve
Issue number5
StatePublished - Nov 2012


  • Hodgkin lymphoma
  • Motor neuron disease
  • Motor neuropathy
  • Paraneoplastic
  • Polyradiculopathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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