PAPP-A: A new anti-aging target?

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

Original languageEnglish (US)
Pages (from-to)942-946
Number of pages5
JournalAging Cell
Issue number6
StatePublished - Dec 2010


  • Insulin-like growth factor
  • Longevity
  • PAPP-A knock-out mice
  • Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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