Abstract
Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML- M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed.
Original language | English (US) |
---|---|
Pages (from-to) | 74-78 |
Number of pages | 5 |
Journal | American journal of hematology |
Volume | 59 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1998 |
Keywords
- Acute myelogenous leukemia
- Bone marrow necrosis
- Bone scan
- CD8+ T cells
ASJC Scopus subject areas
- Hematology