Pancreatoduodenectomy for Chronic Pancreatitis—Results of a Pain Relief and Quality of Life Survey 15 Years Following Operation

Kristopher P. Croome, May Tee, David M. Nagorney, Mark J. Truty, KMarie M. Reid-Lombardo, Florencia G. Que, Michael L. Kendrick, Michael B. Farnell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Over the last 30 years, numerous developments in the management of chronic pancreatitis have occurred, leading to multiple surgical and non-surgical options. Patients and Methods: All patients who underwent pancreatoduodenectomy for chronic pancreatitis from January 1976 to July 2013 were reviewed. Surviving patients were contacted for a follow-up questionnaire and Short Form (SF)-12 Quality of Life Survey administration. Results: A total of 166 patients were identified (cohort 1:1976–1997(N = 105) and cohort 2:1998–2013(N = 61)). Prior to pancreatoduodenectomy, a higher proportion of patients in cohort 2 had undergone endoscopic stenting, 67 vs 10 % (p < 0.001) and/or celiac plexus block 15 and 5 % (p = 0.026). Median follow-up for all survey respondents was 15 years. On the SF-12, mean physical component score was 43.8 ± 11.8 and mental component score was 54.3 ± 7.9. Patients were significantly lower on the physical component score (p < 0.001) and significantly better on the mental component score (p = 0.001) than the general US population. Mean pain score out of 10 was significantly lower after surgery 1.6 ± 2.6 than before surgery 7.9 ± 3.5 (p < 0.001). Diabetes developed in 28 % of patients who were not diabetic prior to surgery. Conclusion: Although practice has changed so that patients have a longer time from presentation until surgery as less-invasive techniques are attempted, pancreatoduodenectomy appears to provide effective long-term pain relief and acceptable quality of life in appropriately selected patients with chronic pancreatitis and intractable pain.

Original languageEnglish (US)
Pages (from-to)2146-2153
Number of pages8
JournalJournal of Gastrointestinal Surgery
Issue number12
StatePublished - Dec 1 2015


  • Chronic pancreatitis
  • Long-term follow-up
  • Pancreatoduodenectomy
  • Whipple

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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