Abstract
The treatment of diabetes mellitus is aimed at improving glycemic control. Establishing relatively tight control using exogenous insulin has been shown to reduce the ophthal-mologic, neurologic and renal complications of diabetes mellitus.1 However, achieving a glycosylated hemoglobin (Hgb A1C) level low enough to reduce secondary complications (a level of approximately 7.0%) is associated with an increased risk of severe, life-threatening hypoglycemia. Both whole organ pancreas transplantation and isolated islet transplantation offer the possibility of even better glycemic control (average Hgb A1C < 6.0%) with the addition of counter-regulatory feedback hormones that avoid life-threatening hypoglycemia.
| Original language | English (US) |
|---|---|
| Title of host publication | Chronic Allograft Failure |
| Subtitle of host publication | Natural History, Pathogenesis, Diagnosis and Management |
| Publisher | CRC Press |
| Pages | 247-251 |
| Number of pages | 5 |
| ISBN (Electronic) | 9781498712729 |
| ISBN (Print) | 9781587061530 |
| DOIs | |
| State | Published - Jan 1 2008 |
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)