PACAP27 and other neuropeptides in the inferior mesenteric ganglion

Leonid G. Ermilov; Joseph H. Szurszewski

doi:10.1111/j.1749-6632.1998.tb11196.x

PACAP₂₇ and other neuropeptides in the inferior mesenteric ganglion

Leonid G. Ermilov, Joseph H. Szurszewski

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The presence and location of PACAP₂₇-like immunoreactivity (PACAP₂₇-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP₂₇ on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.

Original language	English (US)
Pages (from-to)	360-366
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	865
DOIs	https://doi.org/10.1111/j.1749-6632.1998.tb11196.x
State	Published - 1998

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.1998.tb11196.x

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title = "PACAP27 and other neuropeptides in the inferior mesenteric ganglion",

abstract = "The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.",

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doi = "10.1111/j.1749-6632.1998.tb11196.x",

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AU - Ermilov, Leonid G.

AU - Szurszewski, Joseph H.

PY - 1998

Y1 - 1998

N2 - The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.

AB - The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.

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SN - 0077-8923

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SP - 360

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

PACAP₂₇ and other neuropeptides in the inferior mesenteric ganglion

Abstract

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