P-Values and Power in Orthopedic Research: Myths and Reality

Isabella Zaniletti, Katrina L. Devick, Dirk R. Larson, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers

Research output: Contribution to journalArticlepeer-review


The results of statistical tests in orthopedic studies are typically reported using P-values. If a P-value is smaller than the pre-determined level of significance (eg, < .05), the null hypothesis is rejected in support of the alternative. This automaticity in interpreting statistical results without consideration of the power of the study has been denounced over the years by statisticians, since it can potentially lead to misinterpretation of the study conclusions. In this paper, we review fundamental misconceptions and misinterpretations of P-values and power, along with their connection with confidence intervals, and we provide guidelines to orthopedic researchers for evaluating and reporting study results. We provide real-world orthopedic examples to illustrate the main concepts. Please visit the following https://youtu.be/bdPU4luYmF0 for videos that explain the highlights of the paper in practical terms.

Original languageEnglish (US)
Pages (from-to)1945-1950
Number of pages6
JournalJournal of Arthroplasty
Issue number10
StatePublished - Oct 2022


  • P-value
  • arthroplasty
  • orthopedics
  • power
  • sample size
  • significance test

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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